Arife Simsek, Seyfettin Uludag, Abdullah Tuten, Sezin Uludag
Istanbul University, Cerrahpasa School of Medicine, Department of Obstetric and Gynecology, Istanbul, Turkey
Correspondence: Arife Simsek, Istanbul University, Cerrahpasa School of Medicine, Department of Obstetric and Gynecology, Istanbul, Turkey, Tel: +90 536 4764197, E – mail: email@example.com
Objective: The aim of this study is to evaluate obstetric outcomes among women with chronic hypertension, with and without superimposed preeclampsia, and identify risk factors of superimposed preeclampsia. Material and Methods: This retrospective study included 198 Caucasian women with chronic hypertension (out of 14,424 singleton pregnancies) who delivered in a tertiary care center. Clinical findings, maternal and perinatal outcomes were compared between women with and without superimposed preeclampsia. Results: Superimposed preeclampsia developed in 49.4% (98/198) of women studied. The mean gestational week at delivery and birth weight were significantly lower in women with superimposed preeclampsia (p< 0.05). Incidence of preterm delivery was higher in women with superimposed preeclampsia. Although there weren’t significant differences in frequencies of intrauterine growth restriction, stillbirth, early and late neonatal deaths (p > 0.05), maternal near miss cases were significantly higher in women with superimposed preeclampsia (p < 0.05). Only mean arterial blood pressure [OR: 1,070 (1,008-1,135)] was independently associated with the occurrence of superimposed preeclampsia (p: 0.027).
Conclusions: Adverse maternal outcome was more likely to occur in women with suprerimposed preeclampsia.
Chronic hypertension was associated with adverse perinatal outcome, regardless of superimposed preeclampsia.
Keywords: chronic hypertension, preeclampsia, maternal mortality, perinatal mortality