Oral erythromycin and preterm rupture of membranes in pregnancy

Giannoulis H, Tantanasis T, Daniilidis A, Dinas K, Tzafettas J

2nd Department of Obstetrics and Gynecology, Hippokrateio hospital, Thessaloniki, Greece

Correspondence: Daniilidis A, 9 Smirnis St, GR-56224, Thessaloniki, Greece. E-mail: ange1927@otenet.gr


The aim of our study was to compare the outcome of oral erythromycin in 32 cases of preterm rupture of membranes with that of oral co-amoxiclav (amoxicillin trihydrate and clavulanic acid) used as treatment in 19 cases of preterm rupture of membranes. Mean gestational age did not differ between the two groups (30 weeks), ranging from 26 to 33 weeks. In both groups the same tocolytics (intravenous ritrodrine) and steroids (betamethazone) were administered. All subjects underwent culture of vaginal discharge, full blood count, and measurement of C reactive protein (CRP) and erythrocytes sedimentation rate (ESR). No significant differences were noted between the two groups regarding the recurrence of intrauterine infection. We reached to the same conclusions regarding the infection rate of the neonates.

Keywords: erythromycin, ampicillin, co-amoxiclav, preterm rupture of membranes

p. 209-212