Economou K1, Christopikou D1, Tsorva E1, Handyside A2, Cazlaris H1, Davies S1, Mastrominas M1
1Embryogenesis Assisted Conception unit, 49 Kifissias Avenue, GR-15123 Maroussi, Athens, Greece
2The London Bridge Fertility center of Gynecology and Genetics, London, United Kingdom
Correspondence: Economou Konstantinos, Embryogenesis, 49 Kifissias Avenue, GR-15123 Maroussi, Athens, Greece. E-mail: firstname.lastname@example.org
Α patient with a history of recurrent IVF failures was subjected to preimplantation genetic screening of aneuploidies by DNA microarray comparative genomic hybridisation (a-CGH). Oocytes that had been screened and found chromosomally euploid after biopsy of the first and second polar bodies were used, thereby avoiding the use of donated oocytes. A twin clinical pregnancy was achieved after transfer of three embryos, and two healthy children (one male, one female) were delivered by cesarian section at 33 weeks of gestation, due to development of pre-eclampsia symptoms. This is the first report of birth after application of polar bodies screening by a-CGH in Greece.
Keywords: preimplantation genetic screening (PGS), DNA microarray comparative genomic hybridisation (a-CGH), polar body biopsy, IVF