Thrombophilic disorders in pregnacy: Current trends in diagnosis and treatment

Kyriakidis D, Thanassas I, Tziomaki M

Pregnancy is characterized by increased risk for thromboembolic disease. Inherited and acquired thrombophilia, included in the term thrombophilia, are implicated in the pathogenesis of thromboembolic disease as well as pregnancy complications, including recurrent abortions, intrauterine fetal demise, preeclampsia and abruptio placentae. The clotting mechanism and its disorders …

PAI-1 activity and polymorphism 4G/5G in women with idiopathic recurrent miscarriage

Sotiriadis A, Stefos T, Pavlou M, Kolaitis N, Vartholomatos G, Dova L, Paraskevaidis E, Kalantaridou S

Plasminogen activator inhibitor (PAI) indirectly affects trophoblastic invasion, antagonising the promoting effect of urokinase-type plasminogen activator (uPA). Plasminogen activator inhibitor (PAI) levels and the distribution of PAI-1 gene 4G/5G polymorphism were examined in 46 women with ≥2 consecutive unexplained first trimester abortions and 34 matched controls …