Medical management of preterm labor

Thanassas J, Koukoura Ο, Κoumantakis G, Sifakis S

Preterm birth is the leading cause of infant mortality and morbidity. The rate of preterm birth has steadily increased over the past two decades, possibly associated with the increase of the use of assisted reproductive treatments and the limited effectiveness of tocolysis. Tocolytic agents may postpone preterm labor for a short time, enough for the action of corticosteroids and the transfer …

The tocolytic action of the oxytocin receptors antagonist-Atosiban

Sifakis S, Thanasas J, Koumantakis G, Augoustinakis E

In the treatment of preterm labor a variety of tocolytic agents have been used, including β-adrenergic agonists, magnesium sulphate, non-steroids antiinflammatory drugs, Ca++ blocking channels, and progesterone. β2-agonists have been widely used as the first-line tocolytic treatment for preterm labor for many years. They reduce the probability of onset of the labor within 48 hours …

Tocolysis in preterm labor: Always safe?

Pantazis K, Asimakopoulos E, Bontis JN

Preterm labor is the most important single determinant affecting neonatal mortality and morbidity, as well as quality of life. Although large progress has been seen in neonatal care, little has been achieved so far in the treatment of preterm labor, despite of the large number of treatments that have been tried. The traditional use of tocolysis has not been shown to improve neonatal …