Incidence of malignancy in patients treated for infertility with assisted reproduction techniques

Hudecek R1, Ventruba P1, Tsompos C1, Racanska E1, Vavrusova R1, Sarmanova J2, Novak J3
1Obstetrics and Gynecology clinic, Masaryk University, Brno, Czech Republic
2Technology Training Institute of Electrical Engineering and Informatics, Ostrava, Czech Rebublic
3National Service of Czechish Oncology, Brno, Czech Rebublic

Correspondence: Hudecek Robert, Obstetrics and Gynecology clinic, Masaryk University, Brno, Czech Republic. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.




We investigated the potential relation between assisted reproduction technology (ART) and the risk of ovarian carcinoma (OC) by data analysis of our University-based clinical register and National Oncology Register of Czech republic (NOR). Analyzed data included 12,527 assisted reproduction treatment cycles performed at 4,360 patients within years 1982-2004. Among the 4,360 patients, 41 malignancies occured including 6 OC, a value 3.45 times (95%CI: 1.63-6.72, p=0.004)) over the expected incidence. Further investigation is needed to verify whether the same risk excists for the general population referred to infertility treatment.

Key words: infertility; assisted reproduction; ovarian cancer