Role of fibronectin in cellular migration in malignancies of the female tract.

Grammatikakis Ι, Botsis D, Grigoriou O, Dalamaga A, Creatsas G.

2nd Dept. of Obstetrics and Gynecology Clinic University of Athens, Aretaieio Hospital, Athens, Greece.

Correspondence: Grammatikakis I, 105 Likourgou str., 176 72 Kalithea, Αthens, Greece, 

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.




Intense interest is noted in medical literature on the molecule of fibronectin and its participation in pathogenesis of malignant diseases the last decade. Fibronectin has the ability to attach to intracellular, extracellular and surface proteins participating by that way to the mechanisms of healing wounds. We must also emphasize the opsonic action of fibronectin and the fact that levels of fibronectin tend to change in infections. The role of fibronectin in cellular migration and dispersion of malignant cells is probably a fact, but the question remains whether increased levels of fibronectin in women's plasma can be a predictive or a prognostic factor. Aim of the current review is to collect all the data up to today concerning the functions of fibronectin and its role in pathogenesis of malignancies of the female genital tract.

Key words: fibronectin; malignancies; female genital tract.