Antimicrobial prophylaxis in gynecological surgeries

Ziogos E1, Κoukoura O1, Fragouli Y2, Μatalliotakis J1

1Department of Obstetrics and Gynecology, University of Crete, Herakleio, Greece
2Department of Hygiene and Epidemiology, University of Athens, Athens, Greece

Correspondence: Ziogos E, 30 Madinias St, Peristeri, GR-12136, Athens, Greece




The aim of antibiotic prophylaxis during gynecological surgery is to prevent postoperative infection of the surgical site and reduce postoperative infections, morbidity and mortality andthereby reduce the duration and the cost of postoperative healthcare. The wide spread use of antibiotic prophylaxis has reduced but not eliminated serious postoperative infections . For most operations a single dose of
a limited-spectrum drug has been shown to be as effective as a multidose regimen. The surgical procedures associated with the highest risk for postoperative infections are vaginal, abdominal and radical hysterectomy. Both the American College of Obstetricians and Gynecologists and the American Society of Health System Pharmacists have recommended single dose prophylactic protocols using a variety of agents (penicillins, cephalosporins, and clindamycin). However, it remains doubtful whether appropriate prophylaxis is used widely.

Key words: antimicrobial prophylaxis; gynecological surgery