Beta-defensins 2 and 3 in second trimester amniotic fluid as predictorsnof preterm labor

Iavatso C(1), Τassis Κ(2), Gourgiotis D(1), Boutsikou Μ(1), Baka S(1), Chasiakos D(1), Chatzithomas Α(2), 

Souka Α(1), Botsis D(1),  Malamitsi-Puchner A(1). 

(1) 2nd Dept of Obstetrics & Gynecology, University of Athens, Areteio Hospital, Athens, Greece. 
(2) Dept. of Fetal Medicine “Lito” Hospital, Athens, Greece. 

Correspondence: Iavatso C, 38 Seizani str., 14231 N. Ionia, Αthens, Greece

Τel.: +30 6948054119, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.





Human beta-defensins 2 and 3 are peptides expressed in the amnion and chorion. The objective of this study was to investigate whether second trimester amniotic fluid human beta defensins 2 and 3 could be a potential marker of preterm labor prediction. Women giving a preterm delivery were defined as cases (N=41) while for each case a woman matched for age with a fullterm delivery served as control (N=41). Conditional logistic regression analysis was used to examine the possible association of human beta defensins 2 and 3 with preterm labor and/or preterm delivery with premature rupture of membranes.
Human beta defensin 2 concentrations were positively associated with preterm premature rupture of membranes (p=0.028) and were indicatively associated with preterm labour (p= 0.082), while no association of human beta defensin 3 and preterm birth was documented. In conclusion, second trimester amniotic fluid human beta defensin 2 might be a predictor of premature rupture of membranes.

Key words: beta defensins; cytokine; preterm labor; premature rupture of membranes.