Thrombophilic disorders in pregnacy: Current trends in diagnosis and treatment

Kyriakidis D, Thanassas I, Tziomaki M

Department of Obstetrics and Gynecology, Trikala general hospital, Trikala, Greece

Correspondence: Kyriakidis D, Trikala general hospital, GR-42100, Trikala, Greece. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.




Pregnancy is characterized by increased risk for thromboembolic disease. Inherited and acquired thrombophilia, included in the term thrombophilia, are implicated in the pathogenesis of thromboembolic disease as well as pregnancy complications, including recurrent abortions, intrauterine fetal demise, preeclampsia and abruptio placentae. The clotting mechanism and its disorders are currently a field of intense research. We discuss the clinical entities included in the term thrombophilia, their pathogenesis and clinical manifestations, as well as current trends in diagnosis and treatment of thrombophilia in pregnancy.

Key words: pregnancy; thrombophilia; hypercoagulability; thromboprophylaxis