Use of NSAIDs in pregnancy

Felesakis I, Kortesidis Ε, Τosounidou Z, Τsouknidas S, Soilemetzidis G, Karamanidou P

Department of Obstetrics and Gynecology, Drama general hospital, Drama, Greece

Correspondence: Felesakis Ioannis, 9 Simeonidi St, GR-54352, Thessaloniki, Greece.

 


 

Abstract

Use of non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy is common. They are separated in two categories, selective and conventional anti-inflammatory drugs. Aspirin is the most frequently used NSAID, followed by indomethacin. Their use in the first trimester of pregnancy has not been associated with an increase of miscarriage risk. However, when they are prescribed at the periimplantation period there is a significantly increased risk for unsuccessful implantation. Their use after 32nd week of pregnancy is related to early closure or construction of ductus arteriosus, persistent fetal palmonary hypertension, intracranial hemorrhages and renal toxicity in fetuses. Dosage, duration of therapy, and week of pregnancy are the factors that should be considered when these medications are used in pregnancy.
 

Key words: non-steroidal anti-inflammatory drugs; pregnancy; miscarriage; abortion