Changes of maternal plasma Thioredoxin (TRX) in preeclamptic pregnancy

Vitoratos N, Economou E, Vlachos N, Panoulis K,Creatsas G.

2nd Department of Obstetrics and Gynecology, University of Athens, “Aretaieio” Hospital.

Correspondence: N. Vitoratos, 76 Vas. Sophias Ave, 115 28 Athens, Greece. 

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Abstract

Introduction: The aim of this study was to investigate changes of maternal plasma Thioredoxin (TRX) levels before and after delivery in preeclamptic and normotensive pregnant women.
Methods: 10 normotensive women (group A) were compared to 17 women with severe preeclampsia (group B). TRX levels were assessed in maternal plasma before, immediately after delivery and 12-14 weeks postpartum.
Results: There were no differences in plasma TRX levels between the two groups antepartum (p=0,095). A significant reduction in plasma TRX levels was found immediately following delivery only in normotensive group (117.76 ± 37.19 vs 43.45 ± 21.11 ng/ml, p=0,002), but not in women with preeclampsia (80.42 ± 59.95 ng/ml vs 53.82 ± 44.34 ng/ml, p=0,12). Plasma TRX levels remained unchanged in women with preeclampsia (80.42 ± 59.95 ng/ml vs 55.37±52.23 ng/ml, p=0,2), 12-14 weeks postpartum.
Conclusions: We conclude that persistence of TRX levels long after delivery in women with preeclampsia indicates persistence of pregnancy related oxidative stress when the harmful effects of the disease are minimal or totally absent.

Key words: thioredoxin; preeclampsia; oxidative stress; postpartum period.