Molecular mechanisms responsible for the pathogenesis of preeclampsia

Vitoratos N, Panoulis C.

2nd Department of Obstetrics and Gynecology, University of Athens, “Aretaieio” Hospital, Athens, Greece.

Correspondence: N. Vitoratos, 76 Vas. Sophias Ave, 115 28 Athens, Greece, Tel. 210-7286204,

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Abstract

Preeclampsia is one of the leading causes of maternal and perinatal morbidity / mortality. The first step for developing of preeclampsia is the inadequate placental cytotrophoblast invasion and inadequate maternal spiral artery remodelling. However, the clinical appearance of preeclampsia needs the contribution of many molecular mechanisms such as altered angiogenic balance, systemic inflammation, deregulation of Renin-Angiotensin system and placental hypoxia and ischemia. All of these are
analysed in this study.

Key words: preeclampsia; inflammation; VEGF; angiogenesis.