The action of the angiogenetic factors in preeclampsia

Kontomanolis E., Galazios G.

Democritus University in Alexandroupolis, Department of Obstetrics & Gynaecology, Greece

Correspondence: Emmanuel N. Kontomanolis,

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Abstract

Preeclampsia is a multifactorial disease, affecting 5- 7% of pregnancies and causing multiple organ failure (MOF). It is considered to be the main cause of death both for the mother and the newborn. Preeclampsia is also a major cause of fetal growth retardation and premature delivery. The disease is initiated by a multifactorial angiogenetic -mediated process. Clinical research has not been able to lead to any conclusions regarding preeclampsia causes. There has been minor clinical progress in terms of
prognosis in preeclampsia. Research focuses on angiogenic factors during gestation. Insufficient trophoblastic invasion into the spiral arteries and the maternal vascular endothelium are the main features of the disease. Disturbance of the migrating trophoblastic tissue is the starting point for its pathophysiology. Angiogenic factors (PLGF, sEng, sFlt-1) are responsible for the clinical aspects and the severity of the disease. These factors are being expressed in a molecular level and secreted into the
maternal circulation. The angiogenic factors disorganize the anatomical integrity of the vascular endotheliumand predispose to increased arterial pressure, proteinuria, hepatorenal failure, coagulative and neurological sequelae. The validity of the growth factors in a diagnostic level is being widely questioned in preeclamptic subjects among different clinical series.

Key words: preeclampsia; angiogenesis; angiogenetic factors.