The action of VEGF in angiogenesis

Ralli C, Kontomanolis E., Liberis V

Department of Obstetrics and Gynecology, Democritus University of Thrace, Alexandroupolis, Greece

Correspondence: Kontomanolis E, Department of Obstetrics and Gynecology, Democritus University of Thrace, GR-68100, Alexandroupolis, Greece. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 


 

 Abstract

Angiogenesis is a complicated process where new blood vessels are being formed from already pre-existing vessels. For tumor growth and metastases to distant organs, angiogenesis is a biological prerequisite. Tumor cells produce angiogenic factors, including Vascular Endothelial Growth Factor( VEGF), basic Fibroblast Growth Factor (bFGF), Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF), and Transforming Growth Factor beta (TGF-β). VEGF being the most important angiogenic factor, found in four isoforms (VEGF165, VEGF121, VEGF189, VEGF206) and connected to three receptors tyrosine kinase (VEGFR-1, VEGFR-2 and VEGFR-3). Neuropilins (NPRs) are detected in a specific receptor which conforms to VEGF-A.

Key words: angiogenesis; angiogenic factors; tumor; VEGF