Humanin, a cytoprotective peptide against oxidative stress: Is it possible to play a role in obstetrics and gynecology?

Nikolakopoulos P

First department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Papageorgiou hospital, Thessaloniki, Greece

Correspondence: Nikolakopoulos Panagiotis. First Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Papageorgiou hospital, Thessaloniki, Greece. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 


 

Abstract

Humanin is a 24-amino acid peptide encoded by mitochondrial 16SRNA, that was firstly isolated from the occipital lobe of patients with Alzheimer’ s disease. Although it was identified as an antineuronal death factor, literature indicates humanin as a wide spectrum survival factor. To date, humanin has been shown to play a role in preventing cell death among various tissues outside of the nervous system. These studies have broadened the scope of humanin activity and opened up a new field of research. Further studies are needed to clarify the mechanisms underlying these findings and explore the diagnostic or therapeutic implications of humanin in obstetrics and gynecology.
 

Key words: humanin, oxidative stress, preeclampsia, endothelium