2004 Volume 3 – Issue 4

Ovarian regulation of gonadotropin secretion

Dafopoulos KC, Kallitsaris A, Messinis IE

Hypothalamus is the main regulator of reproductive function, responding to both peripheral and central nervous system messages and exerting its influence by means of neurotransmitters transported to the pituitary. Steroidal and non-steroidal ovarian hormones also play a substantial role in the normal reproductive function. During the follicular phase of the normal menstrual cycle …

Effects of SERMs on gonadotropin secretion

Garas A, Kallitsaris A, Messsinis IE

Estrogens are predominant regulators of gonadotrophin secretion during the reproductive years. However, the descriptions of a gene encoding a second type of estrogen receptor, termed ER-β, has prompted a reexamination of the estrogen signaling system and hence of the mechanisms that regulate the gonadotrophin secretion. Recent studies have shown that estrogens may also exert biological …