Improving the performance of Public Hospitals in Greece

Loutradis Dimitris



In order to improve the performance of hospitals within the National Health Service, the Ministry of Health of Greece should identify directions to improve the process, in particular by establishing sound, measurable indicators and set up effective feedback mechanisms. Well-built primary care offers major opportunities for managing and treating the growing burden of chronic diseases. In this way, primary care bypasses the need for acute care services, including emergency medical services (EMS). Without primary care that plays a leading role in managing chronic diseases and avoiding acute care requirements…

Letter to the Editor

Liquid biopsy and ovarian cancer; Where do we stand?

Charalampos Theofanakis, Nikolaos Thomakos, Dimitrios Haidopoulos, Alexandros Rodolakis



Characterized as “silent killer” due to lack of symptoms in the early stages, ovarian cancer represents the most lethal gynecological malignancy. Over the years, there has been an effort to establish effective screening methods in order to assure early detection of the disease. Methods such as serum cancer antigen 125 (CA-125) and transvaginal ultrasound (T/V-US) have been proposed and tested, but with unsatisfactory results, regarding the sensitivity and specificity of the different protocols that are used…

Case Report

Glycogen storage disease type iv: a case with histologic findings in placental tissue from first trimester miscarriage

Anastasia Papakonstantinou, Konstantinos Zacharis, Stavros Kravvaritis, Theodoros Charitos, Eleni Chrysafopoulou, Anastasia Fouka



Glycogen storage disease Type IV is a rare hereditary autosomal recessive disorder caused by deficient enzymatic activity of glycogen branching enzyme (GBE) which is encoded by GBE1 gene. We hereby report the case of a 32-year-old woman presented with a first-trimester miscarriage. The histologic findings of the placental tissue included intracytoplasmic inclusion vacuoles suggested GSD‐IV. The diagnosis was confirmed by the genetic analysis of the parents, in which mother was found to be carrier of a GBE1 mutation…

Case Report

Pemphigus vulgaris in pregnancy. A rare case report

Ioannis Kokolakis, Fanis Makrigiannakis, Sabine Kruger, Konstantinos Krasagakis, Antonios Makrigiannakis



Pemphigus vulgaris (PV) is an autoimmune, bullous, mucocutaneous and potentially life-threatening disease. During pregnancy the occurrence of PV is exceedingly rare and its condition will become more complicated due to different mother’s hormone level and the effect of treatment on both mother and her fetus. PV may be associated with an adverse outcome, such as fetal growth restriction and preterm births. We report a case of a 33-year-old woman who was firstly diagnosed with PV during pregnancy…

Research Article

“Extensive” T4 breast tumors: Considerations regarding local management.

Ioannidis Charilaos



“Extensive” T4 malignant breast tumors are not uncommon and can be either primary or recurrent. Theycan present without or be accompanied by distant metastases at the time of initial presentation. They share one or more of the following symptoms: mass effect, pain, malodor, esthetic distress, exudation, pruritus, bleeding, and crusting. The aim of their treatment is therapeutic, when possible, or palliative, which is quite often the case. A small case series of three female patients with “extensive” T4 breast cancer is presented…

Research Article

Assessment of gynaecological and general history parameters inpregnant women in long term refugee camps in Greece: results from a pilot program

Vasilios Pergialiotis, Chryssoula Botsi, Ioanna Papari, Stavroula Gkritziou, Kassiani Mellou, S. Pappas, Agis Terzidis, Theofilos Rosenberg



Objective:The purpose of the present article is to present preliminary data related to the gynecological history and current health status of pregnant refugees that reside in long-term refugee camps in Greece. Materials and Methods: The study was funded by the European program “PHILOS – Emergency health response to refugee crisis” of the Greek Ministry of Health, implemented by the Hellenic Center for Disease Control and Prevention (HCDCP), funded by the Asylum…

Research Article

The role of Kifc1, Kchn5 and miRNA-302 on in vitro development in 8-cell, morula and blastocyst stage of mouse embryos

Konstantinos Ntzeros, Despoina Mavrogianni, Athina Koutsi, Antonia Kandaraki, Anastasios Papadelas, Sofoklis Stavros, Petros Drakakis, Dimitrios Loutradis



Introduction: Embryo development is characterized by lack of cell cycle check-points and overexpression of core circadian oscillators. On previous report we have identified several genes over-and under-detected at human embryo blastomeres. In this study, we investigated the expression profile of Kcnh5, KIFC1 and miRNA-302 genes at three pre-implantation stages of mouse embryo development. Material and methods: Total RNA was extracted from mouse embyos at 8-cell, morula and blastocyst stage…


Campomelic dysplasia: an overview of a rare genetic disorder

N. Antonakopoulos, D. Vrachnis, N. Loukas, Ch. Christodoulaki, Z. Iliodromiti, N. Vrachnis



Campomelic dysplasia is a rare and severe genetic condition that is characterized by shortening and bowing of the long bones, abnormal face, multiple congenital anomalies, and ambiguous genitalia. Having conducted a review of the existing literature on this rare genetic disorder, we herein present the most pertinent and essential data on the condition viewed from the clinical perspective. In the majority of cases when the neonate survives the condition, since the underlying cause…