Health Care Innovation

Loutradis Dimitris



The exploitation of pharmaceutical innovation has resulted in a 15 – 24% reduction in mortality from malignant diseases worldwide, helping to save resources and ensure productivity by reducing hospitalizations and lost working days. There are currently a large number of new drugs under development aiming at some of the most serious health problems, and the crucial question that arises is: will the patients and the health system in Greece be able to benefit from this huge stream of innovation …


PI3K/PDK1/Akt pathways and their fundamental role in Gynecological Cancer

Sofoklis Stavros, Kalliopi Pappa, Peter Drakakis



The PI3K/PDK1/Akt pathway can regulate a large variety of cellular processes such as cell growth, proliferation and survival. Moreover, it is one of the most frequently altered networks in cancer though. The dysregulation of these pathways has been reported in several human cancers, as well as in diabetes, neurological diseases and cardiovascular diseases. Cervical carcinogenesis seems to be associated with increased levels of activated AKT kinase. Moreover, PTEN inactivation is the most common genetic alteration in type1 endometrial cancer …


Energy sources in gynecologic laparoscopic surgery

Nikolaos Kathopoulis, Athanasios Protopapas, Ioannis Xatzipapas, Panagiotis Antsaklis, Dimitrios Zacharakis, Konstantinos Samartzis, Konstantinos Kipriotis, Dimitrios Loutradis



A number of energy sources are used in gynecologic laparoscopy. Monopolar electrosurgery, bipolar electrosurgery, advanced bipolar devices, ultrasonic energy and various types of lasers are some of the technologies used nowadays to facilitate surgeons tasks during laparoscopic operations. A lack of basic knowledge or ignorance of principles of electrosurgery and equipment among obstetricians and gynecologists is reported. As a result thermal injuries during laparoscopic electrosurgery occur, which frequently lead to significant morbidity and mortality …


Periodontal disease of the mother and incidence of preeclampsia

Thrasyvoulos-Marios Smyrlis, Sofoklis Stavros, Dimitrios Loutradis, Peter Drakakis



Periodontitis is a chronic inflammatory disease, which is progressing in a slow pace and leads to gingival tissue destruction and alveolar bone resorption. If left untreated, it will lead gradually in tooth loss. It is caused by the simultaneous action of bacterial virulence factors and the response of the immune system. In the literature there is growing evidence of a possible link between periodontal disease and systemic health. The relationship between periodontitis and diabetes mellitus3, atherosclerosis and cardiovascular diseases …

Research Article

Laser treatment of twin-to-twin transfusion syndrome (TTTS): preliminary findings from a tertiary center in Greece

Georgios Papaioannou, Nikolaos Evangelinakis, Nikolaos Papantoniou



Background: Twin- to-twin transfusion syndrome (TTTS) affects approximately 15% of monochorionic twin pregnancies with an estimated incidence of 1 in 1,600 pregnancies. The gold standard of care is considered to be Fetoscopic Laser Photocoagulation Therapy (FLPT).  Objective: To present our experience with FLPT in a preliminary prospective observational study. Materials and methods: Fourteen patients who underwent FLPT in the Fetal Maternal Medicine Unit of Attikon University Hospital, between January 2017 and August 2018 …

Research Article

Pilot study: Alternative spliced variants of the Follicle-Stimulating Hormone Receptor gene in Greek women undergoing In Vitro Fertilisation (IVF)

Eudoxia Mamas, Despoina Mavrogianni, Rami Raouasnte, Spyros Karkatzoulis, Emmanouela Liokari, Petros Drakakis, Dimitrios Loutradis



Assisted Reproduction Technology (ART) has proven to be a valuable tool for infertile couples. Unfortunately, no perfect ovarian stimulation protocol has been designed and ovarian response shows great variability among women. Pharmacogenomics aims at detecting genetic markers so as to individualize protocols in order to maximize ovarian response to treatment. Follicle Stimulation hormone receptor (FSHR) mutations and single nucleotide polymorphisms have been extensively studied. Splice variants of the FSHR have been detected in women undergoing in vitro fertilisation (IVF) …

Original Article

Intrahepatic cholestasis of pregnancy (ICP)

Panagiotis Antsaklis, Antonios Koutras, Nikolaos Thomakos, Dimitrios Loutradis



The first chapter of the article presents the general evidence, the clinical manifestation, the pathogenesis and diagnosis of the intrahepatic cholestasis, together with the risks involved for the mother and the fetus. The second chapter presents the treatment goals and the pharmacologic treatment during pregnancy, the management during and after delivery, as well as the risk of recurrence and future goals …