Pregnancy associated cancer: General principles

Ioannis Rellias, Alexandra Tsigginou, Flora Zagouri, Spyridon Marinopoulos, Aris Giannos, Kalliopi Pappa, Constantine Dimitrakakis

Pregnancy associated cancer is defined as the cancer diagnosed during pregnancy or within 1 year postpartum. Since women seem to be delaying childbearing to later ages than in previous generations, the incidence of cancer during pregnancy is constantly increasing. Treatment of cancer during pregnancy is a difficult clinical …


The role of leptin in gynecological oncology

Panagou Paraskevi, Tokatlidou Zoe, Zepiridis Leonidas, Zournatzi Vasiliki

Introduction: Leptin is a hormone which is related with body weight control and sexual maturation. The role of leptin in gynecological diseases is still unclear. The aim of this study was to evaluate levels of leptin in women with benign and malignant tumors of the genital system and to investigate leptin as a potential diagnostic or prognostic marker for the disease course …

Case Report

Office hysteroscopy for the diagnosis of endometrial cancer – An interesting case report

Daniilidis Angelos, Panteleris Nikolaos, Stamkopoulou Anthoula, Carcea Fausto, Kogeorgos Stylianos, Besharat Alexander, Asimakopoulos Efstratios

Introduction: Postmenopausal bleeding (PMB) is defined as bleeding from the genital track one year after the cessation of menses. About 1 in 10 women with postmenopausal bleeding will be diagnosed with malignancy. Case presentation: A 62 year old female patient who presented to the gynecological clinic with two incidents of vaginal bleeding in the last 60 days. The gynecological examination …

Nutrition intervention and quality of life in gynecological oncology

Thomakos N, Petrochilou D, Kontorousis E, Stamatakis E, Rodolakis A, Antsaklis A

Cancer and its treatment result in severe biochemical and physiological alterations associated with deterioration of quality of life (QoL). These metabolic changes leed to decreased food intake and promote catabolism. Cancer-related malnutrition can evolve to cancer cachexia due to complex interactions between pro-inflammatory cytokines and host metabolism. Besides, patients often suffer …

Adnexal masses complicating pregnancy

Thomakos N, Chantzi H, Rodolakis A, Antsaklis A

The management of adnexal masses during pregnancy may be challenging for the patient and the clinician. Adnexal masses may be detected during prenatal ultrasound, and although such masses are rarely malignant (1/10.000 to 1/50.000 pregnancies), the probability of borderline tumor or cancer should always be considered. The etiology of ovarian masses differs according to the patient age …

Proteomics and gynecological cancer

Makedou K, Prapas N, Kourtis A, Makedos G

Proteomics is the study of the complete protein complement of the human genome, the “proteome”. Various technologies have been developed for the purposes of proteomics, such as mass spectrometry. In oncology, proteomics can provide the identification of a panel of proteins, which can be used as biomarkers for early cancer detection, for disease stage determination, for the application …