Mini Review

Conservative therapeutic approach in young patients with endometrial cancer: is it really possible?

Androutsopoulos G, Kotsopoulos C. I, Korompelis P, Michail G, Adonakis G, Decavalas G

Fertility preservation in young patients with early stage endometrial cancer, represents a great therapeutic challenge nowadays. The eligible patients should have strong desire for future fertility, informed consent about conservative approach and no contraindications regarding medical treatment with progestins. Moreover, they should have an extensive counselling regarding disease recurrence, fertility and childbearing issues …

Mini Review

Progestin therapy for patients with endometrial cancer

Tsangouri P. S, Lazarou E, Pappa K

Endometrial cancer is the fifth most common cancer in women worldwide, counting almost 320.000 cases in 2012, and is the sixth leading cause of female death related to cancer. In the United States of America there were 60.050 new endometrial cancer cases in 2016 while in Europe 88.068 and in the United Kingdom about 7.400 cases annually. Atypical endometrial hyperplasia or endometrial intraepithelian neoplasia …


Surveillance of breast cancer patients following primary therapy

Rellias I, Marinopoulos S, Zagouri F, Dimitrakakis C

Objective: To offer a summary of evidence-based recommendations for the surveillance of breast cancer patients after primary treatment. Quality of evidence: A literature search was conducted in Pubmed/MEDLINE using the terms: breast cancer, follow-up, surveillance, survivorship, guidelines and survivorship care plans, with focus on review of recent guidelines published by major cancer organizations…

Research Article

Comparative study of endometrial imaging and cytologic evaluation in perimenopause for the timely diagnosis of endometrial cancer

Vaitsi V, Moschaki V, Chatzistamatiou K, Tsertanidou A, Athanatos D, Athanasiou Ε, Loufopoulos Α, Tarlatzis Β, Agorastos T

Ιntroduction: The aim of the present study was to determine the diagnostic accuracy of sono – hysterography alone or combined with liquid-based cytology (LBC) of endometrium for endometrial lesions detection in perimenopausal women with abnormal uterine bleeding (AUB)…


Molecular biology, expression and clinical significance of ErbB receptors in endometrial cancer

Androutsopoulos Georgios, Michail Georgios, Adonakis Georgios, Decavalas Georgios

The epidermal growth factor system (EGF system) is present in human organs and play important role in cell proliferation, differentiation and apoptosis during embryogenesis and postnatal development. It has 4 receptors (EGFR, ErbB – 2, ErbB – 3 and ErbB – 4) and numerous ligands. Dysregulation of the epidermal growth factor system signaling network, is implicated in the pathogenesis of various disorders …


Systematic lymphadenectomy or sentinel lymph node dissection in endometrial cancer: A clinical dilemma

Georgios Androutsopoulos, Ioannis C. Kotsopoulos, Porfyrios Korompelis, Georgios Michail, Georgios Adonakis, Georgios Decavalas

Endometrial cancer represents a common malignancy of the female reproductive system and systematic surgical staging is the primary therapeutic approach, as offers many advantages in diagnosis, treatment and prognosis. Pelvic and para-aortic lymphadenectomy remains an integral part of the primary surgical therapeutic approach of endometrial cancer and provides substantial …

The sentinel lymph node procedure in gynecologic oncology: Review of the literature

Kalogiannidis I, Xiromeritis P, Prapas Y, Prapas N

Lymphadenectomy contributes to the optimal staging and treatment of patients with gynecologic cancer. However, the former approach is not without adverse outcomes. The aim of the sentinel lymph node (SLN) procedure, which is the first node involved by the tumor, is to detect the group of patients with positive SLN, who will benefit from the lymphadenectomy. On the other hand …