Theodore Liakakos, Katerina Papakonstantinou, Michail Panagiotopoulos, Dimitrios Papageorgiou
Complex adnexal cystic masses in women of reproductive age should be carefully evaluated before the final diagnosis is set. Adnexal cystic masses are not necessary malignant. On the contrary, they usually refer to a benign and not cancerous pathology. A certain benign pathology behind adnexal masses is endometriosis. Endometriosis occurs …
Elli Anagnostou, Agathi Theodoropoulou, Despina Mavrogianni, Athanasios Protopapas, Peter Drakakis, Dimitrios Loutradis
Estrogens and estrogen receptors (ERs) play an important role in the pathogenesis of endometriosis. The aim of this study was to investigate the presence of gene polymorphism RsaI in the gene of the estrogen receptor ERβ in the Greek female population, and its distribution in women suffering from endometriosis and in a control group. We included 67 consecutive infertile women of Caucasian origin who were operated laparoscopically in our Gynecological Endoscopy Unit for endometriosis, and 96 women participated as control group…
Theoni Kanellopoulou
Endometriosis is a chronic inflammatory disease of women of reproductive age that is defined by the presence of ectopic endometrium. The pathophysiology of the disease is poorly understood, however platelet activation play a crucial role in initiation of inflammation and fibrinogenesis, which in term further activate the coagulation cascade. The relationship between inflammation and coagulation motivated researchers to study whether patients are in a hypercoagulable state and if endometriosis represent an independent risk factor for venous thromboembolism or cardiovascular risk. This review article focuses on the role of coagulation, the risk of thrombosis and a possible beneficial effect of antithrombotic-treatment.
Thanasas K. I, Papavasileiou S
The abdominal wall is the most common position locating endometriosis. The presentation of the event concerning the occurrence of endometriosis in scar of laparotomy after cesarean section. A patient, four years after cesarean section performed with Pfannestiel, came to our outpatient clinic with abdominal pain primary located in the left end of the surgical scar. Based on history and clinical findings was the suspected endometriosis …
Timologou A, Ζafrakas Μ, Grimbizis G, MiliarasD, Kotronis K, Tarlatzis Β
Although several theories exist, the etiology and pathogenesis of endometriosis is poorly understood. Data from clinical and laboratory studies indicate that this disease has common characteristics with malignant neoplasms. The present review focuses on the common molecular mechanisms involved in both implantation of tissue at ectopic sites in endometriosis and tumor metastasis …
Chatzopoulos K, Kourtis A, Tantsis A, Agorastos T
The etiopathogenesis of endometriosis is complex. During menstruation, endometrial cells reflux backwards to the peritoneal cavity. In cases of endometriosis these cells have reduced apoptotic response due to activation of oncogenes and deregulation of normal apoptotic mechanisms. By entering the peritoneal cavity, they contact an environment rich in estrogens and growth factors …
Farfaras A, Koliopanos A, Sindos M, Margaris E
Endometriosis is a chronic benign gynecological disease, primary affecting women of reproductive age and characterized by the growth of endometrial cells in ectopic locations. Despite the widespread occurrence of the disorder, little is known of its etiology. Several hypotheses have been proposed to explain its origin. Retrograde menstruation of endometrial cells into the peritoneum …
Papadias K, Αvgoulea A, Lambrinoudaki I, Κreatsa M, Christodoulakos G
Endometriosis is an enigmatic disease, as the etiopathogenetic mechanism remains still unclarified. The classic theories of implantation, induction and metaplasia are unable to give an explanation for all the cases of endometriosis. Based on the classic theories and mainly on the implantation theory of Sampson, many authors tried to analyze immunologic mechanisms responsible …
Karanikolopoulos P, Εvaggelinakis E, Kassanos D
Endometriosis is a disease that affects millions of women around the world, with significant impact on their quality of life. Modern therapeutic approaches mainly aim to relieving women from their symptoms-cronic pelvic pain and infertility-while its potential role as predisposing factor for several types of cancer, especially for ovarian cancer, is still under investigation …
Baliakas D, Deliveliotou E, Giotis C, Vlachos N
Endometriosis and ovarian cancer share many molecular, pathogenetic and predisposing factors. In a molecular basis endometriosis and estrogen-dependent neoplasms respond similarly to estrogen-induced growth signalling. They have common resistance to apoptotic processes, whereas genetic mutations in the presence of endometriosis are associated with certain types of ovarian cancer …