Molecular biology, expression and clinical significance of ErbB receptors in endometrial cancer

Androutsopoulos Georgios, Michail Georgios, Adonakis Georgios, Decavalas Georgios

The epidermal growth factor system (EGF system) is present in human organs and play important role in cell proliferation, differentiation and apoptosis during embryogenesis and postnatal development. It has 4 receptors (EGFR, ErbB – 2, ErbB – 3 and ErbB – 4) and numerous ligands. Dysregulation of the epidermal growth factor system signaling network, is implicated in the pathogenesis of various disorders …

Posted in 2014 Volume 13 – Issue 3 Tagged , , , , ,