Revealing the enigma of coagulation in endometriosis: the risk of thrombosis and the role of antithrombotic treatment

Theoni Kanellopoulou



Endometriosis is a chronic inflammatory disease of women of reproductive age that is defined by the presence of ectopic endometrium. The pathophysiology of the disease is poorly understood, however platelet activation play a crucial role in initiation of inflammation and fibrinogenesis, which in term further activate the coagulation cascade. The relationship between inflammation and coagulation motivated researchers to study whether patients are in a hypercoagulable state and if endometriosis represent an independent risk factor for venous thromboembolism or cardiovascular risk. This review article focuses on the role of coagulation, the risk of thrombosis and a possible beneficial effect of antithrombotic-treatment.

The role of infection and inflammatory response of the mother in preterm premature rupture of membranes: pathophysiologic data

Evangelinakis N, Polyzou E, Kassanos D

Preterm birth, caused either by preterm onset of contractions (before 37 weeks’ gestation) or by preterm premature rupture of membranes (pPROM), accounts for ~80% of preterm deliveries. pPROM is associated with 30-40% of preterm deliveries and its incidence has increased during the past decade. A fundamental question that has to be addressed is why some women experience preterm pPROM …

Endometriosis and ovarian cancer

Baliakas D, Deliveliotou E, Giotis C, Vlachos N

Endometriosis and ovarian cancer share many molecular, pathogenetic and predisposing factors. In a molecular basis endometriosis and estrogen-dependent neoplasms respond similarly to estrogen-induced growth signalling. They have common resistance to apoptotic processes, whereas genetic mutations in the presence of endometriosis are associated with certain types of ovarian cancer …