Maria Fanaki, Paraskevas Perros, Vasilios Pergialiotis, Konstantinos Mpramis, Nikolaos Thomakos
Ovarian cancer is the second most common cause of gynecologic cancer death. The most common histologic category of epithelial ovarian cancer is High Grade Serous Ovarian Cancer (HGSOC). The initial management usually involves appropriate staging and debulking surgery. Otherwise, patients with unresectable disease receive neoadjuvant chemotherapy, and then undergo Interval Debulking Surgery (IDS) …
Machairiotis N, Thomakos N, Malakasis A, Rodolakis A
Ovarian cancer results in the formation and proliferation of abnormal cells that have the ability to proliferate faster than normal/typical ovarian cells and then spread to other parts of the body either in a local or in a systemic way. The areas to which the metastases of ovarian cancer can be located include the lining of the abdomen, lining of the bowel and bladder, lymph nodes, lungs, liver and in very rare cases the skin …
Thomakos N, Chantzi H, Rodolakis A, Antsaklis A
The management of adnexal masses during pregnancy may be challenging for the patient and the clinician. Adnexal masses may be detected during prenatal ultrasound, and although such masses are rarely malignant (1/10.000 to 1/50.000 pregnancies), the probability of borderline tumor or cancer should always be considered. The etiology of ovarian masses differs according to the patient age …
Kalogiannidis I, Xiromeritis P, Prapas Y, Prapas N
Lymphadenectomy contributes to the optimal staging and treatment of patients with gynecologic cancer. However, the former approach is not without adverse outcomes. The aim of the sentinel lymph node (SLN) procedure, which is the first node involved by the tumor, is to detect the group of patients with positive SLN, who will benefit from the lymphadenectomy. On the other hand …
Baliakas D, Deliveliotou E, Giotis C, Vlachos N
Endometriosis and ovarian cancer share many molecular, pathogenetic and predisposing factors. In a molecular basis endometriosis and estrogen-dependent neoplasms respond similarly to estrogen-induced growth signalling. They have common resistance to apoptotic processes, whereas genetic mutations in the presence of endometriosis are associated with certain types of ovarian cancer …
Hudecek R, Ventruba P, Tsompos C, Racanska E, Vavrusova R, Sarmanova J, Novak J
We investigated the potential relation between assisted reproduction technology (ART) and the risk of ovarian carcinoma (OC) by data analysis of our University-based clinical register and National Oncology Register of Czech republic (NOR). Analyzed data included 12,527 assisted reproduction treatment cycles performed at 4,360 patients within years 1982-2004. Among the 4,360 patients …
Chilaris GH, Tsoumpis T, Alarkof E, Karkotis K, Daveta A
The role of laparoscopy in the management of abdominopelvic malignancies is constantly evolving. Recebt data from clinical trials demonstrate that laparoscopic surgical staging has equal efficacy (lymph node counts, disease free survival) compared to traditional open cases and can be safely performed in selected patients. We report a case of laparoscopic radical hysterectomy …