{"id":347,"date":"2017-08-16T20:21:46","date_gmt":"2017-08-16T20:21:46","guid":{"rendered":"http:\/\/5.189.150.156\/~hjog\/?p=347"},"modified":"2017-09-11T21:43:28","modified_gmt":"2017-09-11T21:43:28","slug":"pai-1-activity-and-polymorphism-4g5g-in-women-with-idiopathic-recurrent-miscarriage","status":"publish","type":"post","link":"https:\/\/hjog.org\/?p=347","title":{"rendered":"PAI-1 activity and polymorphism 4G\/5G in women with idiopathic recurrent miscarriage"},"content":{"rendered":"<p>Sotiriadis A<sup>1<\/sup>, Stefos T<sup>1<\/sup>, Pavlou M<sup>1<\/sup>, Kolaitis N<sup>2<\/sup>, Vartholomatos G<sup>3<\/sup>, Dova L<sup>3<\/sup>, Paraskevaidis E<sup>1<\/sup>, Kalantaridou S<sup>1<\/sup><\/p>\n<p><sup>1<\/sup>Department of Obstetrics and Gynecology, University of Ioannina, Ioannina, Greece<br \/>\n<sup>2<\/sup>Hematology Laboratory, University of Ioannina, Ioannina, Greece<br \/>\n<sup>3<\/sup>Unit of Molecular Biology, University of Ioannina, Ioannina, Greece<\/p>\n<p><em>Correspondence:<\/em> Sotiriadis A, 10 P. Mela St, GR-54622 Thessaloniki, Greece. E-mail: asotir@gmail.com<\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/hjog.org\/wp-content\/pdf\/2008\/251-255_2008.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-130\" src=\"https:\/\/hjog.org\/wp-content\/uploads\/2017\/08\/pdf-icons-free-icons-in-file-icons-18.png\" alt=\"\" width=\"48\" height=\"48\" \/><\/a><\/p>\n<hr \/>\n<h5>Abstract<\/h5>\n<p>Plasminogen activator inhibitor (PAI) indirectly affects trophoblastic invasion, antagonising the promoting effect of urokinase-type plasminogen activator (uPA). Plasminogen activator inhibitor (PAI) levels and the distribution of PAI-1 gene 4G\/5G polymorphism were examined in 46 women with \u22652 consecutive unexplained first trimester abortions and 34 matched controls. Although women with recurrent miscarriages showed increased median PAI activity, compared with controls (2.5 U\/mL versus 0.4 U\/mL, P=0.001), the distribution of the polymorphism did not differ between the two groups. Recurrent miscarriage patients have higher PAI activity, which is likely part of a wider prothrombotic state, on which the specific PAI-1 gene polymorphism has little effect.<\/p>\n<p><em>Keywords:<\/em> recurrent miscarriages, PAI, thrombophilia, fibrinolysis<\/p>\n<p>p. 251-255<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sotiriadis A, Stefos T, Pavlou M, Kolaitis N, Vartholomatos G, Dova L, Paraskevaidis E, Kalantaridou S<\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/hjog.org\/wp-content\/pdf\/2008\/251-255_2008.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-130\" src=\"https:\/\/hjog.org\/wp-content\/uploads\/2017\/08\/pdf-icons-free-icons-in-file-icons-18.png\" alt=\"\" width=\"48\" height=\"48\" \/><\/a><\/p>\n<p>Plasminogen activator inhibitor (PAI) indirectly affects trophoblastic invasion, antagonising the promoting effect of urokinase-type plasminogen activator (uPA). Plasminogen activator inhibitor (PAI) levels and the distribution of PAI-1 gene 4G\/5G polymorphism were examined in 46 women with \u22652 consecutive unexplained first trimester abortions and 34 matched controls &#8230;<\/p>\n<p><a href=\"<?php echo get_permalink(); ?>&#8220;> Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38],"tags":[317,315,314,316],"class_list":["post-347","post","type-post","status-publish","format-standard","hentry","category-2008-volume-7-issue-3","tag-fibrinolysis","tag-pai","tag-recurrent-miscarriages","tag-thrombophilia"],"_links":{"self":[{"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/posts\/347","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hjog.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=347"}],"version-history":[{"count":3,"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/posts\/347\/revisions"}],"predecessor-version":[{"id":949,"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/posts\/347\/revisions\/949"}],"wp:attachment":[{"href":"https:\/\/hjog.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=347"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hjog.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=347"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hjog.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=347"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}