{"id":617,"date":"2017-09-04T19:50:30","date_gmt":"2017-09-04T19:50:30","guid":{"rendered":"http:\/\/5.189.150.156\/~hjog\/?p=617"},"modified":"2022-02-04T14:48:13","modified_gmt":"2022-02-04T14:48:13","slug":"meta-analysis-vaginal-misoprostol-prostin-for-intrauterine-insemination-%ce%b1-meta-analysis-of-randomized-trials","status":"publish","type":"post","link":"https:\/\/hjog.org\/?p=617","title":{"rendered":"Vaginal misoprostol (Prostin\u00ae) for intrauterine insemination: A meta &#8211; analysis of randomized trials"},"content":{"rendered":"<p><span style=\"color: #ff9900;\">Meta-analysis<\/span><\/p>\n<p>Pergialiotis Vasilios<sup>1<\/sup>, Frountzas Maximos<sup>1<\/sup>, Stefanidis Konstantinos<sup>2<\/sup>, Prodromidou Anastasia<sup>1<\/sup>, Perrea Despina<sup>1<\/sup>, Vlachos D Georgios<sup>2<\/sup><\/p>\n<p><sup>1<\/sup>Laboratory of Experimental Surgery and Surgical Research \u201cN Christeas\u201d, University of Athens, Medical school, Athens, Greece<br \/>\n<sup>2<\/sup>First department of Obstetrics and Gynecology, University of Athens, Medical school, Alexandra hospital, Athens, Greece<\/p>\n<p><em>Correspondence:<\/em> Pergialiotis Vasilios, 6 Danaidon st, Halandri, GR &#8211; 15232, Athens, Greece, E &#8211; mail: pergialiotis@yahoo.com<\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/hjog.org\/wp-content\/pdf\/2015\/Vaginal_misoprostol_Prostin_for_intrauterine_insemination_\u0391_meta_-_analysis_of_randomized_trials.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-130\" src=\"https:\/\/hjog.org\/wp-content\/uploads\/2017\/08\/pdf-icons-free-icons-in-file-icons-18.png\" alt=\"\" width=\"48\" height=\"48\" \/><\/a><\/p>\n<hr \/>\n<h5>Abstract<\/h5>\n<p>Introduction: The seminal fluid contains prostaglandins which seem to be important during the fertilization process. However, these are cleaved during semen preparation for intrauterine insemination (IUI). The purpose of the present meta &#8211; analysis is to investigate if vaginal application of prostaglandin E (PGE) improves the pregnancy rates among women undergoing IUI. Materials and methods: We systematically searched Pubmed (1966 &#8211; 2015), Scopus (2004 &#8211; 2015), ClinicalTrials. gov (2008 &#8211; 2015), Cochrane Central Register (CENTRAL) and Google Scholar (2004 &#8211; 2015) for published randomized controlled trials (RCTs). Statistical meta-analysis was performed using the RevMan 5.1 software. Results: Six RCTs were included in the present meta-analysis which enrolled 1,403 women. PGE placement in the posterior vaginal fornix immediately after the IUI did not improve the pregnancy rates per cycle (1,734 cycles, OR= 1.16, 95% CI: 0.80 &#8211; 1.67). The most frequent adverse effects were abdominal cramping and vaginal spotting. Conclusion: Routine use of PGE is not justified among women undergoing IUI because it does not seem to improve the pregnancy rates and it is associated with adverse effects. However, further studies are needed in the field because our meta-analysis is restricted by the low number of included RCTs.<\/p>\n<p><em>Keywords:<\/em> intrauterine insemination, prostaglandin E, misoprostol, sperm, infertility<\/p>\n<p>p. 72-79<\/p>\n<hr \/>\n","protected":false},"excerpt":{"rendered":"<p>Pergialiotis Vasilios, Frountzas Maximos, Stefanidis Konstantinos, Prodromidou Anastasia, Perrea Despina, Vlachos D Georgios<\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/hjog.org\/wp-content\/pdf\/2015\/Vaginal_misoprostol_Prostin_for_intrauterine_insemination_\u0391_meta_-_analysis_of_randomized_trials.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-130\" src=\"https:\/\/hjog.org\/wp-content\/uploads\/2017\/08\/pdf-icons-free-icons-in-file-icons-18.png\" alt=\"\" width=\"48\" height=\"48\" \/><\/a><\/p>\n<p>Introduction: The seminal fluid contains prostaglandins which seem to be important during the fertilization process. However, these are cleaved during semen preparation for intrauterine insemination (IUI). The purpose of the present meta &#8211; analysis is to investigate if vaginal application of prostaglandin E (PGE) improves the pregnancy rates among women undergoing IUI.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[66],"tags":[224,631,536,632,633],"class_list":["post-617","post","type-post","status-publish","format-standard","hentry","category-2015-volume-14-issue-3","tag-infertility","tag-intrauterine-insemination","tag-misoprostol","tag-prostaglandin-e","tag-sperm"],"_links":{"self":[{"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/posts\/617","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hjog.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=617"}],"version-history":[{"count":7,"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/posts\/617\/revisions"}],"predecessor-version":[{"id":2713,"href":"https:\/\/hjog.org\/index.php?rest_route=\/wp\/v2\/posts\/617\/revisions\/2713"}],"wp:attachment":[{"href":"https:\/\/hjog.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hjog.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hjog.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}