Research Article

Comparative study of endometrial imaging and cytologic evaluation in perimenopause for the timely diagnosis of endometrial cancer

Vaitsi V, Moschaki V, Chatzistamatiou K, Tsertanidou A, Athanatos D, Athanasiou Ε, Loufopoulos Α, Tarlatzis Β, Agorastos T

Ιntroduction: The aim of the present study was to determine the diagnostic accuracy of sono – hysterography alone or combined with liquid-based cytology (LBC) of endometrium for endometrial lesions detection in perimenopausal women with abnormal uterine bleeding (AUB)…


Molecular biology, expression and clinical significance of ErbB receptors in endometrial cancer

Androutsopoulos Georgios, Michail Georgios, Adonakis Georgios, Decavalas Georgios

The epidermal growth factor system (EGF system) is present in human organs and play important role in cell proliferation, differentiation and apoptosis during embryogenesis and postnatal development. It has 4 receptors (EGFR, ErbB – 2, ErbB – 3 and ErbB – 4) and numerous ligands. Dysregulation of the epidermal growth factor system signaling network, is implicated in the pathogenesis of various disorders …


Systematic lymphadenectomy or sentinel lymph node dissection in endometrial cancer: A clinical dilemma

Georgios Androutsopoulos, Ioannis C. Kotsopoulos, Porfyrios Korompelis, Georgios Michail, Georgios Adonakis, Georgios Decavalas

Endometrial cancer represents a common malignancy of the female reproductive system and systematic surgical staging is the primary therapeutic approach, as offers many advantages in diagnosis, treatment and prognosis. Pelvic and para-aortic lymphadenectomy remains an integral part of the primary surgical therapeutic approach of endometrial cancer and provides substantial …

The sentinel lymph node procedure in gynecologic oncology: Review of the literature

Kalogiannidis I, Xiromeritis P, Prapas Y, Prapas N

Lymphadenectomy contributes to the optimal staging and treatment of patients with gynecologic cancer. However, the former approach is not without adverse outcomes. The aim of the sentinel lymph node (SLN) procedure, which is the first node involved by the tumor, is to detect the group of patients with positive SLN, who will benefit from the lymphadenectomy. On the other hand …