Current knowledge on common molecular mechanisms involved in endometriosis and tumor metastasis

Timologou A, Ζafrakas Μ, Grimbizis G, MiliarasD, Kotronis K, Tarlatzis Β

Although several theories exist, the etiology and pathogenesis of endometriosis is poorly understood. Data from clinical and laboratory studies indicate that this disease has common characteristics with malignant neoplasms. The present review focuses on the common molecular mechanisms involved in both implantation of tissue at ectopic sites in endometriosis and tumor metastasis …

The etiopathogenesis of endometriosis

Chatzopoulos K, Kourtis A, Tantsis A, Agorastos T

The etiopathogenesis of endometriosis is complex. During menstruation, endometrial cells reflux backwards to the peritoneal cavity. In cases of endometriosis these cells have reduced apoptotic response due to activation of oncogenes and deregulation of normal apoptotic mechanisms. By entering the peritoneal cavity, they contact an environment rich in estrogens and growth factors …

Endometriosis and dioxins

Farfaras A, Koliopanos A, Sindos M, Margaris E

Endometriosis is a chronic benign gynecological disease, primary affecting women of reproductive age and characterized by the growth of endometrial cells in ectopic locations. Despite the widespread occurrence of the disorder, little is known of its etiology. Several hypotheses have been proposed to explain its origin. Retrograde menstruation of endometrial cells into the peritoneum …

Pathogenesis of endometriosis: Classic theories and recent data

Papadias K, Αvgoulea A, Lambrinoudaki I, Κreatsa M, Christodoulakos G

Endometriosis is an enigmatic disease, as the etiopathogenetic mechanism remains still unclarified. The classic theories of implantation, induction and metaplasia are unable to give an explanation for all the cases of endometriosis. Based on the classic theories and mainly on the implantation theory of Sampson, many authors tried to analyze immunologic mechanisms responsible …

Endometriosis: Newer data of the disease pathogenesis

Karanikolopoulos P, Εvaggelinakis E, Kassanos D

Endometriosis is a disease that affects millions of women around the world, with significant impact on their quality of life. Modern therapeutic approaches mainly aim to relieving women from their symptoms-cronic pelvic pain and infertility-while its potential role as predisposing factor for several types of cancer, especially for ovarian cancer, is still under investigation …

Endometriosis and ovarian cancer

Baliakas D, Deliveliotou E, Giotis C, Vlachos N

Endometriosis and ovarian cancer share many molecular, pathogenetic and predisposing factors. In a molecular basis endometriosis and estrogen-dependent neoplasms respond similarly to estrogen-induced growth signalling. They have common resistance to apoptotic processes, whereas genetic mutations in the presence of endometriosis are associated with certain types of ovarian cancer …