Preimplantation Genetic Diagnosis

Loutradis Dimitris

A benefit of the state-of-the-art in assistant reproductive treatment requires among others, a definitive preimplantation genetic diagnosis (PGD) as an alternative to prenatal diagnosis, for couples with a family history of a genetic disease. In the past, parents had to take the risk for an inherited genetic disorder, or undergo prenatal diagnostic testing and pregnancy termination …

Case Report

First live birth in Greece after blastocyst trophectoderm biopsy and preimplantation genetic diagnosis by karyomapping

Economou A.K , Wells D, Christopikou D, Tsorva E, Davies S, Mastrominas M

Preimplantation genetic diagnosis for single gene defects is a well established tool in assisted reproduction. Karyomapping is a genome-wide parental haplotyping technology using a high density single nucleotide polymorphism array that allows the diagnosis of any single gene defects and the majority of aneuploidies from the same embryonic sample post embryo biopsy. A couple, carriers of different cystic fibrosis (CF) mutations …


Assisted Reproduction Techniques; What’s old and what’s new

Panagakis G, Asimakopoulos G, Sfakianakis A, Theofanakis Ch, Kallianidis K, Drakakis P

The greatest achievement of assisted reproductive medicine was the birth of Louise Brown in 1978. It was the result of many efforts by Edwards & Steptoe to achieve pregnancy with in vitro fertilization (IVF). Since then, there has been a rapid development of assisted reproduction techniques, with the ultimate aim of making infertility treatment more effective and affordable for most couples. The thorough study …


Surveillance of breast cancer patients following primary therapy

Rellias I, Marinopoulos S, Zagouri F, Dimitrakakis C

Objective: To offer a summary of evidence-based recommendations for the surveillance of breast cancer patients after primary treatment. Quality of evidence: A literature search was conducted in Pubmed/MEDLINE using the terms: breast cancer, follow-up, surveillance, survivorship, guidelines and survivorship care plans, with focus on review of recent guidelines published by major cancer organizations…

Case Report

Ovarian cysts in pregnancy. When surgical treatment required and when monitoring preferred?

Kalmantis K, Petsa A, Alexopoulos E, Daskalakis G, Rodolakis A

Introduction: Ovarian cysts occur in 3% of pregnancies. Usually, they do not have clinical symptoms and are found accidentally during the ultrasound screening performed in the 1st trimester of pregnancy. Materials and Methods: Articles were identified through electronic databases; no date or language restrictions were placed; relevant citations were hand searched. The search was conducted using the following terms …