PAI-1 activity and polymorphism 4G/5G in women with idiopathic recurrent miscarriage

Sotiriadis A, Stefos T, Pavlou M, Kolaitis N, Vartholomatos G, Dova L, Paraskevaidis E, Kalantaridou S

Plasminogen activator inhibitor (PAI) indirectly affects trophoblastic invasion, antagonising the promoting effect of urokinase-type plasminogen activator (uPA). Plasminogen activator inhibitor (PAI) levels and the distribution of PAI-1 gene 4G/5G polymorphism were examined in 46 women with ≥2 consecutive unexplained first trimester abortions and 34 matched controls …

Posted in 2008 Volume 7 – Issue 3 Tagged , , ,