Makedou K, Prapas N, Kourtis A, Makedos G
Proteomics is the study of the complete protein complement of the human genome, the “proteome”. Various technologies have been developed for the purposes of proteomics, such as mass spectrometry. In oncology, proteomics can provide the identification of a panel of proteins, which can be used as biomarkers for early cancer detection, for disease stage determination, for the application …
Kouskouti C, Kousteni E, Christopoulos P, Deligeoroglou E
The polycystic ovary syndrome (PCOS), mainly characterized by clinical and/or biochemical hyperandrogenism, ovarian dysfunction and/or polycystic morphology and associated metabolic disorders, is the most common endocrine disorder in women of reproductive age. The observed aggregation of PCOS cases within the same families and the persuasion that the interaction between multiple genetic …
Kalogiannidis I, Xiromeritis P, Prapas Y, Prapas N
Lymphadenectomy contributes to the optimal staging and treatment of patients with gynecologic cancer. However, the former approach is not without adverse outcomes. The aim of the sentinel lymph node (SLN) procedure, which is the first node involved by the tumor, is to detect the group of patients with positive SLN, who will benefit from the lymphadenectomy. On the other hand …
Αvgoulea A, Lambrinoudaki I, Creatsa M, Kaligerou I, Botsis D
Vulvovaginal fungal infection is one of the most common infections of the genital tract. Candida albicans is the most important cause of the infection. The presence of candida albicans in the vaginal liquid is not necessarily a pathologic finding and should be examined in correlation with the presence of the classical symptoms which include pruritus, dysuria and dyspareunia …
Sotiriadis A, Stefos T, Pavlou M, Kolaitis N, Vartholomatos G, Dova L, Paraskevaidis E, Kalantaridou S
Plasminogen activator inhibitor (PAI) indirectly affects trophoblastic invasion, antagonising the promoting effect of urokinase-type plasminogen activator (uPA). Plasminogen activator inhibitor (PAI) levels and the distribution of PAI-1 gene 4G/5G polymorphism were examined in 46 women with ≥2 consecutive unexplained first trimester abortions and 34 matched controls …
Gregoriades T, Athanasiou S, Zisou A, Sotiropoulou M, Antsaklis A
To assess current practices regarding episiotomy and the repair of obstetric perineal injuries among Greek obstetricians and gynecologists and to identify any relative training deficiencies, a questionnaire was sent to obstetricians and gynecologists practicing in the Athens area. 121 out of 130 questionnaires were completed. An episiotomy was always performed by 50% of the doctors …
Diamantopoulou S, Karanikolopoulos P, Kassanos D
Pregnancy related osteoporosis is a rare disease. Both etiology and mechanism remain unknown. Pregnancy causes considerable alterations in calcium levels, in hormones regulating calcium levels and homeostasis as well as a gradual decline of bone mineral density (BMD). Osteoporosis may also appear during the puerperium or affect pregnant teenagers. The usual symptoms are low back pain …
Papadias K, Αvgoulea A, Lambrinoudaki I, Κreatsa M, Christodoulakos G
Endometriosis is an enigmatic disease, as the etiopathogenetic mechanism remains still unclarified. The classic theories of implantation, induction and metaplasia are unable to give an explanation for all the cases of endometriosis. Based on the classic theories and mainly on the implantation theory of Sampson, many authors tried to analyze immunologic mechanisms responsible …
Thanassas J, Koukoura Ο, Κoumantakis G, Sifakis S
Preterm birth is the leading cause of infant mortality and morbidity. The rate of preterm birth has steadily increased over the past two decades, possibly associated with the increase of the use of assisted reproductive treatments and the limited effectiveness of tocolysis. Tocolytic agents may postpone preterm labor for a short time, enough for the action of corticosteroids and the transfer …