PAI-1 activity and polymorphism 4G/5G in women with idiopathic recurrent miscarriage

Sotiriadis A1, Stefos T1, Pavlou M1, Kolaitis N2, Vartholomatos G3, Dova L3, Paraskevaidis E1, Kalantaridou S1

1Department of Obstetrics and Gynecology, University of Ioannina, Ioannina, Greece
2Hematology Laboratory, University of Ioannina, Ioannina, Greece
3Unit of Molecular Biology, University of Ioannina, Ioannina, Greece

Correspondence: Sotiriadis A, 10 P. Mela St, GR-54622 Thessaloniki, Greece. E-mail:


Plasminogen activator inhibitor (PAI) indirectly affects trophoblastic invasion, antagonising the promoting effect of urokinase-type plasminogen activator (uPA). Plasminogen activator inhibitor (PAI) levels and the distribution of PAI-1 gene 4G/5G polymorphism were examined in 46 women with ≥2 consecutive unexplained first trimester abortions and 34 matched controls. Although women with recurrent miscarriages showed increased median PAI activity, compared with controls (2.5 U/mL versus 0.4 U/mL, P=0.001), the distribution of the polymorphism did not differ between the two groups. Recurrent miscarriage patients have higher PAI activity, which is likely part of a wider prothrombotic state, on which the specific PAI-1 gene polymorphism has little effect.

Keywords: recurrent miscarriages, PAI, thrombophilia, fibrinolysis

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