Duloxetine: A new and innovative solution for urinary stress incontinence, the role of serotonine and noradrenaline

Kolovos VD

Department of Urogynecology and disorders rehabilitation of pelvic background, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieio hospital, Athens, Greece

Correspondence: Kolovos VD, 34 Sinopis St, GR-11527 Goudi, Athens, Greece


In the current therapies for urinary stress incontinence there are still needs to be met. One of the main issues is to find safe and effective solutions for the management of the stress incontinence, as we still do not have worldwide drugs widely accepted. Drug therapies used outside the indications have not been proven effective and unwanted effects are usually found. Duloxetine is the first drug used for urinary stress incontinence. It acts on the CNS and not on the periphery, and so it reduces the danger of the urine retention. The first results of using duloxetine for more than 12 weeks have been encouraging as there has been an impressive improvement in the quality of life of patients suffering from urinary stress incontinence. The percentage of patients stopping the therapy because of nausea is very small. As a conclusion, we strongly believe that duloxetine will become a safe and effective solution for women suffering from urinary stress incontinence.

Key words: duloxetine, urinary stress incontinence, drug treatment

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