Short Communication

Polycystic ovary-like abnormalities and Single Nucleotide Polymorphisms as potential biomarkers for controlled ovarian stimulation outcome; A novel approach

Theofanakis Charalampos1, Anagnostou Elli2, Mavrogianni Despoina3, Besharat Alexandros1, Loutradis Dimitrios1

11st Department of Obstetrics & Gynecology, Alexandra hospital, National &Kapodistrian University of Athens, Athens, Greece
2Department of Endocrinology, Alexandra hospital, Athens, Greece
3Department of Reproductive & Regenerative Medicine, Alexandra hospital, National &Kapodistrian University of Athens, Athens, Greece

Correspondence: Charalampos Theofanakis MD, M.Sc, Ph.Dc, Agiou Pavlou 23, 12132 Peristeri, Athens, Greece, E-mail:


Polycystic ovary – like (PCO-L) abnormalities is a condition characterized by normally menstruating cycles, sporadic anovulation and no known infertility. These women usually present with hyperandrogenism, without polycystic ovarian morphology. With the present study, we attempted to evaluate the role of single nucleotide polymorphisms of FSH and Estrogen Receptors to the outcome of assisted reproduction techniques, in patients with PCO-L. We demonstrated that certain genotypes lead to higher pregnancy rates. Further studies need to be made in order to clarify the ideal ovulation induction protocol in patients with PCO-L.

Keywords: hyperandrogenism, polycystic ovary-like abnormalities, poor responders, single nucleotide polymorphisms, ovulation induction