Makedou K, Prapas N, Kourtis A, Makedos G
Proteomics is the study of the complete protein complement of the human genome, the “proteome”. Various technologies have been developed for the purposes of proteomics, such as mass spectrometry. In oncology, proteomics can provide the identification of a panel of proteins, which can be used as biomarkers for early cancer detection, for disease stage determination, for the application …
Kouskouti C, Kousteni E, Christopoulos P, Deligeoroglou E
The polycystic ovary syndrome (PCOS), mainly characterized by clinical and/or biochemical hyperandrogenism, ovarian dysfunction and/or polycystic morphology and associated metabolic disorders, is the most common endocrine disorder in women of reproductive age. The observed aggregation of PCOS cases within the same families and the persuasion that the interaction between multiple genetic …
Kalogiannidis I, Xiromeritis P, Prapas Y, Prapas N
Lymphadenectomy contributes to the optimal staging and treatment of patients with gynecologic cancer. However, the former approach is not without adverse outcomes. The aim of the sentinel lymph node (SLN) procedure, which is the first node involved by the tumor, is to detect the group of patients with positive SLN, who will benefit from the lymphadenectomy. On the other hand …
Αvgoulea A, Lambrinoudaki I, Creatsa M, Kaligerou I, Botsis D
Vulvovaginal fungal infection is one of the most common infections of the genital tract. Candida albicans is the most important cause of the infection. The presence of candida albicans in the vaginal liquid is not necessarily a pathologic finding and should be examined in correlation with the presence of the classical symptoms which include pruritus, dysuria and dyspareunia …
Sotiriadis A, Stefos T, Pavlou M, Kolaitis N, Vartholomatos G, Dova L, Paraskevaidis E, Kalantaridou S
Plasminogen activator inhibitor (PAI) indirectly affects trophoblastic invasion, antagonising the promoting effect of urokinase-type plasminogen activator (uPA). Plasminogen activator inhibitor (PAI) levels and the distribution of PAI-1 gene 4G/5G polymorphism were examined in 46 women with ≥2 consecutive unexplained first trimester abortions and 34 matched controls …
Gregoriades T, Athanasiou S, Zisou A, Sotiropoulou M, Antsaklis A
To assess current practices regarding episiotomy and the repair of obstetric perineal injuries among Greek obstetricians and gynecologists and to identify any relative training deficiencies, a questionnaire was sent to obstetricians and gynecologists practicing in the Athens area. 121 out of 130 questionnaires were completed. An episiotomy was always performed by 50% of the doctors …
Diamantopoulou S, Karanikolopoulos P, Kassanos D
Pregnancy related osteoporosis is a rare disease. Both etiology and mechanism remain unknown. Pregnancy causes considerable alterations in calcium levels, in hormones regulating calcium levels and homeostasis as well as a gradual decline of bone mineral density (BMD). Osteoporosis may also appear during the puerperium or affect pregnant teenagers. The usual symptoms are low back pain …
Papadias K, Αvgoulea A, Lambrinoudaki I, Κreatsa M, Christodoulakos G
Endometriosis is an enigmatic disease, as the etiopathogenetic mechanism remains still unclarified. The classic theories of implantation, induction and metaplasia are unable to give an explanation for all the cases of endometriosis. Based on the classic theories and mainly on the implantation theory of Sampson, many authors tried to analyze immunologic mechanisms responsible …
Thanassas J, Koukoura Ο, Κoumantakis G, Sifakis S
Preterm birth is the leading cause of infant mortality and morbidity. The rate of preterm birth has steadily increased over the past two decades, possibly associated with the increase of the use of assisted reproductive treatments and the limited effectiveness of tocolysis. Tocolytic agents may postpone preterm labor for a short time, enough for the action of corticosteroids and the transfer …
Grammatikakis J, Evaggelinakis N, Kassanos D
Acute viral hepatitis is the most common cause of jaundice in pregnancy. Chronic hepatitis B or D infections may be transmitted to the neonate. However, hepatitis B virus transmission is effectively prevented with perinatal hepatitis B vaccination and prophylaxis with hepatitis B immune globulin. Cholelithiasis occurs in 6% of pregnancies. Complications can be safely treated …
Karanikolopoulos P, Εvaggelinakis E, Kassanos D
Endometriosis is a disease that affects millions of women around the world, with significant impact on their quality of life. Modern therapeutic approaches mainly aim to relieving women from their symptoms-cronic pelvic pain and infertility-while its potential role as predisposing factor for several types of cancer, especially for ovarian cancer, is still under investigation …
Μakris N, Vomvolaki E, Αntsaklis A
Diagnostic hysteroscopy is an examination method of the endometrial cavity, used since the 19th century. The development of technology improved the instruments which are required. Hysteroscopy has been increasingly used as first line investigation for the diagnosis and the treatment of many diseases involving the uterine cavity. The purpose of this study was to report the hysteroscopic …
Pados G, Almaloglou K, Bontis J
Postoperative adhesions are a significant complication of all abdominal surgical procedures. Adhesions formation is a consequence of peritoneal trauma and may lead to infertility, bowel obstruction and chronic pelvic pain. The major strategies for adhesion prevention are focused to the optimization of surgical technique and the use of antiadhesive agents which fall into two main categories …