Mamopoulos A
Methods of prenatal diagnosis for chromosomal abnormalities: The disadvantages
Prophylactic and therapeutic vaccines against HPV infection
Kontou S, Chaidogiannos K, Trianti M, Salamalekis E
Persistent infection with one of the oncogenic HPV types is necessary for the development of cervical cancer. The role of HPV in cervical carcinogenesis and their immune response have created expectations for prevention. Vaccines based on the induction of neutralizing antibodies against the HPV structural proteins L1 and L2 are termed “prophylactic”. Vaccines based on the induction …
The contribution of the transvaginal hysterosonography in the evaluation of postmenopausal bleeding
Skartados N, Kalmandis K, Papadoniou N, Daskalakis G, Mesogitis S, Antsaklis A
The aim of our study was to identify the role of transvaginal hysterosonography (HS) in postmenopausal women with unexplained bleeding. Sixty six women with unexplained metrorrhage, aged between 49 and 64 years were included in the study. After a transvaginal ultrasound, a saline hysterosonography was performed in all cases. Following this, all women were referred for dilatation …
Total uterine prolapse as the main cause of severe obstructive nephropathy: A case report
Toufexi E, Giannakopoulos K, Lagadas A, Sarikakis J, Provataki C, Zorbala A, Stamatiadis D, Kiriakidou K, Astraka M
Total uterine prolapse may lead to severe obstructive nephropathy. We report a case of a 77 years old woman who presented with complete uterovaginal prolapse, bilateral hydronephrosis, arterial hypertension and renal failure. A complete correction of her renal failure was observed after the surgical repair of the prolapse (vaginal hysterectomy followed by anterior and posterior …
Advantages of GnRH antagonists over the agonists in IVF
Dafopoulos KC, Messinis IE
GnRH antagonists were introduced in IVF in the late 1990s. They are effective in reliable prevention of premature LH surge and luteinization during superovulation and their safety is well documented. Two different antagonist protocols have been developed: the multiple dose protocol and the single dose protocol. GnRH antagonists have many advantages compared to agonists …
GnRH agonists or antagonists in ovarian stimulation
Loutradis D, Stefanidis K, Antsaklis A, Michalas S
Ovarian stimulation is an important step in the success rate of in vitro fertilization (IVF) allowing multiple follicular growth and oocytes retrieval, and, consequently, more embryos. Blockade of pituitary gonadotrophin secretion occurs upon desensitization when a continuous GnRH stimulus is provided by means of an agonist or when pituitary receptors are occupied with a competitive …
Tocolysis in preterm labor: Always safe?
Pantazis K, Asimakopoulos E, Bontis JN
Preterm labor is the most important single determinant affecting neonatal mortality and morbidity, as well as quality of life. Although large progress has been seen in neonatal care, little has been achieved so far in the treatment of preterm labor, despite of the large number of treatments that have been tried. The traditional use of tocolysis has not been shown to improve neonatal …
Combined chemoradiotherapy in locally advanced cancer of the uterine cervix
Trichas M, Tserkezoglou A, Barbounis V, Hatzieleftheriou G, Roupakia A, Giannakouras G, Katsilieris I
The purpose of this phase II study is to investigate the response and toxicity of combined pelvic radiotherapy and cisplatin-based chemotherapy and overall survival of women with locally advanced cancer of the uterine cervix. A total of 28 eligible patients out of 33 initially enrolled in the study with stage IIB-IVA were studied and received 4 cycles of cisplatin chemotherapy …
Vacuum versus forceps delivery: Maternal and neonatal outcomes
Prapas N, Kalogiannidis I, Diamanti E, Karagiannidou E, Papanikolaou A, Makedos A, Drossou- Agakidou V, Makedos G
The purpose of our study was to estimate the differences in maternal and neonatal outcomes in singleton term pregnancies delivered using forceps or vacuum. We retrospectively studied the instrumental vaginal deliveries that occurred from January 2000 to June 2004 in the 4th Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki. Multiple gestations …
Primary ovarian pregnancy: A case report
Grimbizis G, Papadopoulos NP, Mikos T, Tzitzimikas S, Papanikolaou A, Tsalikis T, Bontis J
Ovarian ectopic pregnancies are uncommon with an incidence of 2.5-3.5% of extrauterine pregnancies. ART, IUCD’s and PID are the most important risk factors. A case of a ruptured ovarian ectopic that was treated laparoscopically is presented. Transvaginal ultrasound and serum hCG measurement facilitate early diagnosis of ectopic pregnancies. Minimally invasive endoscopic techniques …
The cardiotocography during labor: The negative
The cardiotocography during labor: The benefit
Ovarian regulation of gonadotropin secretion
Dafopoulos KC, Kallitsaris A, Messinis IE
Hypothalamus is the main regulator of reproductive function, responding to both peripheral and central nervous system messages and exerting its influence by means of neurotransmitters transported to the pituitary. Steroidal and non-steroidal ovarian hormones also play a substantial role in the normal reproductive function. During the follicular phase of the normal menstrual cycle …
Effects of SERMs on gonadotropin secretion
Garas A, Kallitsaris A, Messsinis IE
Estrogens are predominant regulators of gonadotrophin secretion during the reproductive years. However, the descriptions of a gene encoding a second type of estrogen receptor, termed ER-β, has prompted a reexamination of the estrogen signaling system and hence of the mechanisms that regulate the gonadotrophin secretion. Recent studies have shown that estrogens may also exert biological …