Editorial

Dimitris Loutradis

Assisted reproductive technology (ART) has evolved considerably over the last decades, incorporating advances in ovarian stimulation, embryology, cryobiology, reproductive genetics, and laboratory medicine. Contemporary ART aims not only to achieve fertilization and embryo implantation but also to optimize cumulative live birth rates while minimizing treatment-related risks …

The role of Hysterosalpingo-foam sonography in the evaluation of female infertility

Styliani Chondrou, Konstantinos Kalmantis, Efstathios Tepetzikiotis, Sotirios Kalogeropoulos, Georgios Daskalakis, Nikolaos Thomakos

Introduction: Assessment of fallopian tube patency represents a fundamental component of the infertility work-up, as tubal factor infertility remains a common cause of female subfertility. Conventional diagnostic methods, such as hysterosalpingography and laparoscopy, are associated …

Methodological validation and pilot evaluation of apoptosis-related microRNAs in human cumulus cells as candidate biomarkers of embryo quality in IVF

Tsorva Erikaiti, Kakourou Georgia, Christopikou Dimitra, Davies Stephen, Zacharia Stavroula, Sfontouris Ioannis, Makrakis Evangelos, Frysira Helen, Tzetis Maria, Mastrominas Minas, Traeger-Synodinos Joanne

Background: Embryo selection remains one of the principal determinants of success in assisted reproductive technology (ART). Current selection methods rely primarily on morphological assessment, which provides only indirect and imperfect prediction of embryo developmental competence and implantation potential …

Neurobiological Insights and Treatment Advances in Postpartum Depression (PPD)

Abhijit Dutta, Mannat Sahu, S. Jayakumari, Vivek Kumar Jha, K.S.Sridevi Sangeetha, Rajkumar Krishnan Vasanthi, Kambam Jessica Reddy, Kumaraswamy Dabburu

Postpartum depression (PPD) remains a major public health and psychiatric concern, persisting as an underdiagnosed and insufficiently managed condition despite advancements in global healthcare systems. Clinically, PPD typically manifests within the first four weeks to one year postpartum and is characterized by persistent low mood …

Vitamin D and Pregnancy Loss: Biological Plausibility, Clinical Evidence and Current Controversies

Dimitra Papakosta, Nikolaos Roussos, Tilemachos Karalis, Panagiotis Tsavalos, Grigorios F. Grimbizis, Angelos Daniilidis

Introduction: Vitamin D, beyond its classical role in calcium homeostasis and bone metabolism, exerts immunomodulatory and paracrine effects in reproductive tissues. Emerging evidence suggests a potential link between maternal vitamin D deficiency and miscarriage, particularly recurrent pregnancy loss …

Psychoeducational Intervention Prevents Weight Gain in Gestational Diabetes Mellitus: A Feasibility and Pilot Study

Koptsi I, Tsapekos D, Papadimitriou K, Athanasiadou E, Goulis DG

Pubic symphysis diastasis in pregnancy is a rare obstetric complication. A case of a 35 year old primigravid woman with severe pubic symphysis diastasis and sacroiliac joint relaxation during non-operative vaginal delivery is reported and the literature reviewed. The patient was successfully treated by open reduction and internal fixation with plate and screws …

Legal and Bioethical Aspects of Surrogacy

Maria Anastasia Chatzi, Themistoklis Dagklis, Nikolaos Dagklis, Apostolos Mamopoulos, Maria Milapidou

Surrogacy is a form of medically assisted reproduction that raises complex legal and bioethical issues, as it challenges traditional concepts of motherhood, family, and kinship. This study is based on a review of Greek legislation on medically assisted reproduction, comparative analysis of selected European legal systems …

Bioethics and the Use of Stem Cells

Theoklitos Pantelides

Bioethics is an interdisciplinary scientific field that examines ethical, legal, and social issues arising from advances in medicine and biotechnology. Among the most debated topics in contemporary bioethics is the use of stem cells, particularly embryonic stem cells, which raise fundamental questions …

Differential Expression of miR-99a and miR-143 in Sperm and Follicular Fluid Samples from Couples Undergoing ART: Implications for Embryo Quality and Human Infertility

Eleni Nazou, Despoina Mavrogianni, Anastasios Potiris, Efthalia Moustakli, Ekaterini Domali, Periklis Panagopoulos, George Daskalakis, Peter Drakakis, Sofoklis Stavros

Follicular fluid (FF) and semen contain microRNAs (miRNAs), important regulators of reproductive physiology and potential non-invasive biomarkers of infertility. This study examined miR-99a and miR-143 expression in infertile couples undergoing assisted reproductive technology (ART) and their correlations with reproductive characteristics in sperm …