Current knowledge on common molecular mechanisms involved in endometriosis and tumor metastasis

Timologou A, Ζafrakas Μ, Grimbizis G, MiliarasD, Kotronis K, Tarlatzis Β

Although several theories exist, the etiology and pathogenesis of endometriosis is poorly understood. Data from clinical and laboratory studies indicate that this disease has common characteristics with malignant neoplasms. The present review focuses on the common molecular mechanisms involved in both implantation of tissue at ectopic sites in endometriosis and tumor metastasis …

Posted in 2011 Volume 10 – Issue 3 Tagged , , ,

The etiopathogenesis of endometriosis

Chatzopoulos K, Kourtis A, Tantsis A, Agorastos T

The etiopathogenesis of endometriosis is complex. During menstruation, endometrial cells reflux backwards to the peritoneal cavity. In cases of endometriosis these cells have reduced apoptotic response due to activation of oncogenes and deregulation of normal apoptotic mechanisms. By entering the peritoneal cavity, they contact an environment rich in estrogens and growth factors …

Posted in 2011 Volume 10 – Issue 2 Tagged , ,