First live birth in Greece after blastocyst trophectoderm biopsy and preimplantation genetic diagnosis by karyomapping

Economou A.K , Wells D, Christopikou D, Tsorva E, Davies S, Mastrominas M

Preimplantation genetic diagnosis for single gene defects is a well established tool in assisted reproduction. Karyomapping is a genome-wide parental haplotyping technology using a high density single nucleotide polymorphism array that allows the diagnosis of any single gene defects and the majority of aneuploidies from the same embryonic sample post embryo biopsy. A couple, carriers of different cystic fibrosis (CF) mutations …

Posted in 2017 Volume 16 – Issue 3 Tagged , , ,

Live birth after polar body biopsy and preimplantation genetic screening of aneuploidy by DNA-microarray comparative genomic hybridisation

Economou K, Christopikou D, Tsorva E, Handyside A, Cazlaris H, Davies S, Mastrominas M

Α patient with a history of recurrent IVF failures was subjected to preimplantation genetic screening of aneuploidies by DNA microarray comparative genomic hybridisation (a-CGH). Oocytes that had been screened and found chromosomally euploid after biopsy of the first and second polar bodies were used, thereby avoiding the use of donated oocytes. A twin clinical pregnancy was achieved …

Posted in 2012 Volume 11 – Issue 1 Tagged , , ,