Homocysteine, cardiovascular disease and hormone replacement therapy in post-menopausal women

Deligeoroglou Ε, Tsimaris P, Deliveliotou A

Homocysteine (Hcy) is a sulfated amino acid deriving from methionine. Hcy’s metabolism, as well as the association of Hcy with cardiovascular disease (CVD) are extensively illustrated in this review article. The precise mechanism by which Hcy is involved in the pathogenesis and establishment of CVD, which is the leading cause of morbidity and mortality in postmenopausal women …

Posted in 2005 Volume 4 – Issue 3 Tagged , , ,

Prophylactic and therapeutic vaccines against HPV infection

Kontou S, Chaidogiannos K, Trianti M, Salamalekis E

Persistent infection with one of the oncogenic HPV types is necessary for the development of cervical cancer. The role of HPV in cervical carcinogenesis and their immune response have created expectations for prevention. Vaccines based on the induction of neutralizing antibodies against the HPV structural proteins L1 and L2 are termed “prophylactic”. Vaccines based on the induction …

Posted in 2005 Volume 4 – Issue 2 Tagged , , , , ,

The contribution of the transvaginal hysterosonography in the evaluation of postmenopausal bleeding

Skartados N, Kalmandis K, Papadoniou N, Daskalakis G, Mesogitis S, Antsaklis A

The aim of our study was to identify the role of transvaginal hysterosonography (HS) in postmenopausal women with unexplained bleeding. Sixty six women with unexplained metrorrhage, aged between 49 and 64 years were included in the study. After a transvaginal ultrasound, a saline hysterosonography was performed in all cases. Following this, all women were referred for dilatation …

Posted in 2005 Volume 4 – Issue 2 Tagged , , ,

Total uterine prolapse as the main cause of severe obstructive nephropathy: A case report

Toufexi E, Giannakopoulos K, Lagadas A, Sarikakis J, Provataki C, Zorbala A, Stamatiadis D, Kiriakidou K, Astraka M

Total uterine prolapse may lead to severe obstructive nephropathy. We report a case of a 77 years old woman who presented with complete uterovaginal prolapse, bilateral hydronephrosis, arterial hypertension and renal failure. A complete correction of her renal failure was observed after the surgical repair of the prolapse (vaginal hysterectomy followed by anterior and posterior …

Posted in 2005 Volume 4 – Issue 2 Tagged , , , , ,

Advantages of GnRH antagonists over the agonists in IVF

Dafopoulos KC, Messinis IE

GnRH antagonists were introduced in IVF in the late 1990s. They are effective in reliable prevention of premature LH surge and luteinization during superovulation and their safety is well documented. Two different antagonist protocols have been developed: the multiple dose protocol and the single dose protocol. GnRH antagonists have many advantages compared to agonists …

Posted in 2005 Volume 4 – Issue 1 Tagged , , ,