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PI3K/PDK1/Akt pathways and their fundamental role in Gynecological Cancer

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Sofoklis Stavros, Kalliopi Pappa, Peter Drakakis

 

 

The PI3K/PDK1/Akt pathway can regulate a large variety of cellular processes such as cell growth, proliferation and survival. Moreover, it is one of the most frequently altered networks in cancer though. The dysregulation of these pathways has been reported in several human cancers, as well as in diabetes, neurological diseases and cardiovascular diseases. Cervical carcinogenesis seems to be associated with increased levels of activated AKT kinase. Moreover, PTEN inactivation is the most common genetic alteration in type1 endometrial cancer …

Posted in 2019 Volume 18 – Issue 4

Energy sources in gynecologic laparoscopic surgery

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Nikolaos Kathopoulis, Athanasios Protopapas, Ioannis Xatzipapas, Panagiotis Antsaklis, Dimitrios Zacharakis, Konstantinos Samartzis, Konstantinos Kipriotis, Dimitrios Loutradis

 

 

A number of energy sources are used in gynecologic laparoscopy. Monopolar electrosurgery, bipolar electrosurgery, advanced bipolar devices, ultrasonic energy and various types of lasers are some of the technologies used nowadays to facilitate surgeons tasks during laparoscopic operations. A lack of basic knowledge or ignorance of principles of electrosurgery and equipment among obstetricians and gynecologists is reported. As a result thermal injuries during laparoscopic electrosurgery occur, which frequently lead to significant morbidity and mortality …

Posted in 2019 Volume 18 – Issue 4 Tagged , , ,

Periodontal disease of the mother and incidence of preeclampsia

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Thrasyvoulos-Marios Smyrlis, Sofoklis Stavros, Dimitrios Loutradis, Peter Drakakis

 

 

Periodontitis is a chronic inflammatory disease, which is progressing in a slow pace and leads to gingival tissue destruction and alveolar bone resorption. If left untreated, it will lead gradually in tooth loss. It is caused by the simultaneous action of bacterial virulence factors and the response of the immune system. In the literature there is growing evidence of a possible link between periodontal disease and systemic health. The relationship between periodontitis and diabetes mellitus3, atherosclerosis and cardiovascular diseases …

Posted in 2019 Volume 18 – Issue 4 Tagged , ,

Laser treatment of twin-to-twin transfusion syndrome (TTTS): preliminary findings from a tertiary center in Greece

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Georgios Papaioannou, Nikolaos Evangelinakis, Nikolaos Papantoniou

 

 

Background: Twin- to-twin transfusion syndrome (TTTS) affects approximately 15% of monochorionic twin pregnancies with an estimated incidence of 1 in 1,600 pregnancies. The gold standard of care is considered to be Fetoscopic Laser Photocoagulation Therapy (FLPT).  Objective: To present our experience with FLPT in a preliminary prospective observational study. Materials and methods: Fourteen patients who underwent FLPT in the Fetal Maternal Medicine Unit of Attikon University Hospital, between January 2017 and August 2018 …

Posted in 2019 Volume 18 – Issue 4 Tagged , , , ,

Intrahepatic cholestasis of pregnancy (ICP)

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Panagiotis Antsaklis, Antonios Koutras, Nikolaos Thomakos, Dimitrios Loutradis

 

 

The first chapter of the article presents the general evidence, the clinical manifestation, the pathogenesis and diagnosis of the intrahepatic cholestasis, together with the risks involved for the mother and the fetus. The second chapter presents the treatment goals and the pharmacologic treatment during pregnancy, the management during and after delivery, as well as the risk of recurrence and future goals …

Posted in 2019 Volume 18 – Issue 4 Tagged , , ,

Pilot study: Alternative spliced variants of the Follicle-Stimulating Hormone Receptor gene in Greek women undergoing In Vitro Fertilisation (IVF)

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Eudoxia Mamas, Despoina Mavrogianni, Rami Raouasnte, Spyros Karkatzoulis, Emmanouela Liokari, Petros Drakakis, Dimitrios Loutradis

 

 

Assisted Reproduction Technology (ART) has proven to be a valuable tool for infertile couples. Unfortunately, no perfect ovarian stimulation protocol has been designed and ovarian response shows great variability among women. Pharmacogenomics aims at detecting genetic markers so as to individualize protocols in order to maximize ovarian response to treatment. Follicle Stimulation hormone receptor (FSHR) mutations and single nucleotide polymorphisms have been extensively studied. Splice variants of the FSHR have been detected in women undergoing in vitro fertilisation (IVF) …

Posted in 2019 Volume 18 – Issue 4 Tagged , , , ,

Improving the performance of Public Hospitals in Greece

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Loutradis Dimitris

 

 

In order to improve the performance of hospitals within the National Health Service, the Ministry of Health of Greece should identify directions to improve the process, in particular by establishing sound, measurable indicators and set up effective feedback mechanisms. Well-built primary care offers major opportunities for managing and treating the growing burden of chronic diseases. In this way, primary care bypasses the need for acute care services, including emergency medical services (EMS). Without primary care that plays a leading role in managing chronic diseases and avoiding acute care requirements…

Posted in 2019 Volume 18 – Issue 3

Campomelic dysplasia: an overview of a rare genetic disorder

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N. Antonakopoulos, D. Vrachnis, N. Loukas, Ch. Christodoulaki, Z. Iliodromiti, N. Vrachnis

 

 

Campomelic dysplasia is a rare and severe genetic condition that is characterized by shortening and bowing of the long bones, abnormal face, multiple congenital anomalies, and ambiguous genitalia. Having conducted a review of the existing literature on this rare genetic disorder, we herein present the most pertinent and essential data on the condition viewed from the clinical perspective. In the majority of cases when the neonate survives the condition, since the underlying cause…

Posted in 2019 Volume 18 – Issue 3 Tagged , , ,

The role of Kifc1, Kchn5 and miRNA-302 on in vitro development in 8-cell, morula and blastocyst stage of mouse embryos

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Konstantinos Ntzeros, Despoina Mavrogianni, Athina Koutsi, Antonia Kandaraki, Anastasios Papadelas, Sofoklis Stavros, Petros Drakakis, Dimitrios Loutradis

 

 

Introduction: Embryo development is characterized by lack of cell cycle check-points and overexpression of core circadian oscillators. On previous report we have identified several genes over-and under-detected at human embryo blastomeres. In this study, we investigated the expression profile of Kcnh5, KIFC1 and miRNA-302 genes at three pre-implantation stages of mouse embryo development. Material and methods: Total RNA was extracted from mouse embyos at 8-cell, morula and blastocyst stage…

Posted in 2019 Volume 18 – Issue 3 Tagged , , , , ,